Adenosine and blood platelets

Platelets and Blood Cells

Wound healing is a complex response of the organism aiming to restore tissue integrity and organ function. In skin, vascular and inflammatory changes predominate for the first 3-5 days after wounding. The following granulation phase is characterized by new connective tissue production and re-epithelialization (1). In the mid-phase of cutaneous tissue repair, fibroblasts that have invaded the gr...

Fine structural localization of adenosine triphosphatase in human platelets and other blood cells.

By JAMES G. WHITE AND WILLIAM Knivrr T lIE UTILIZATION of adenosine triphosphate ( ATP) by human platelets during clot formation and retraction is important to the functioning of these cells in clotting physiology.’ 2 Recent developments in histochemical and electron microscopic methods have permitted identification of enzymes hydrolyzing ATP at the fine structural level.t We have applied these...

Blood Platelets and Systemic Sclerosis

Systemic sclerosis (SSc) is characterized by a progressive fibrosis of the perivascular and interstitial connective tissues which can involve the skin, heart, lungs, kidneys, and the gastrointestinal tract. SSc is an uncommon, debilitating condition, associated to a vital risk linked to visceral extensions and has a high case-fatality rate among connectivitis. SSc begins in the vast majority of...

Effects of catecholamines on the formation of adenosine 3':5'-cyclic monophosphate in human blood platelets.

Adenosine diphosphate receptors on blood platelets: potential new targets for antiplatelet therapy.

Platelets play a key role not only in physiological haemostasis, but also under pathological conditions such as thrombosis. Platelet activation may be initiated by a variety of agonists including thrombin, collagen, thromboxane or adenosine diphosphate (ADP). Although ADP is regarded as a weak agonist of blood platelets, it remains an important mediator of platelet activation evoked by other ag...